Why Antidepressants Don’t Live Up to the Hype

In the ’90s, Americans grew fond of the idea that you can fix depression simply by taking a pill — most famously fluoxetine , though fluoxetine is just one of at least seven selective serotonin reuptake inhibitors that have been prescribed to treat hundreds of millions of people around the world. But in the past few years, researchers have challenged the effectiveness of Prozac and other SSRIs in several studies. For instance, a review published in the Journal of Affective Disorders in February attributed 68% of the benefit from antidepressants to the placebo effect

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